Cancer Research

A Cancer Cure 40 years ago, the use of Peptides

petide_cancer All cancer drugs share a problem: They penetrate just a few cells into the tumor. Now a team of biologists has identified a molecule that helps cancer treatments dive deep into tumors, at least in mice. The approach still needs to be tested in people, but if it pans out, it will circumvent one of the biggest challenges in the field. “This has huge implications for cancer therapy,” says David Cheresh, a tumor and vascular biologist at the University of California (UC), San Diego, who was not involved in the work. source: news.sciencemag.org/sciencenow/2010/04/new-peptide-helps-cancer-drugs-b.html

Peptides have emerged as important therapeutics that are being rigorously tested in angiogenesis-dependent diseases due to their low toxicity and high specificity. Since the discovery of endogenous proteins and protein fragments that inhibit microvessel formation (thrombospondin, endostatin) several peptides have shown promise in pre-clinical and clinical studies for cancer. source: US National Library of Medicine/National Institutes of Health

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